| ncRNA name | HMGB1 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Mus musculus |
| Tissues/Cell_line | retinal ganglion cell line RGC-5 |
| Methods | siRNA transfection, qPCR, ELISA, MTT assay, Western blot |
| Expression pattern | associated |
| Functional description | HMGB-1 can inhibit inflammation and promote RGCs survival to delay DR progress through the HMGB-1-TLR4-NF-κB signaling pathway. SiRNA HMGB-1 transfection obviously inhibited HMGB-1 mRNA expression , reduced HMGB-1 secretion, and decreased TLR4 and NF-κB mRNA and protein expression. |
| PubMed ID | 26454330 |
| Year | 2015 |
| Title | HMGB-1 as a Potential Target for the Treatment of Diabetic Retinopathy. |
| Drug-related ncRNA | NO |
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